Areas of Expertise

Bacteriology, Microbial Genetics, Geospatial Information Systems

Wastewater Indicators of Antibiotic-resistance in the Community

Antimicrobial resistance (AMR) is a major global threat with the potential of once-treatable infections becoming untreatable. To preserve antimicrobials, both the global and local authorities, the World Health Organization and the Australian Commission of Quality and Safety in Health Care, recognise that it is imperative to start monitoring AMR in the general community. Monitoring trends in priority pathogens in the general community is, however, a methodological challenge. Mass-population monitoring for a variety of biomarkers, including illicit drugs, using untreated samples from wastewater (WW) treatment plants (WWTPs) has been shown to provide representative samples of the general community. Hence, the research goal is to establish wastewater as a monitoring tool for antimicrobial resistance (AMR) in the general community on a regional and national scale. Wastewater influents samples around Sydney will be tested for multi-drug resistance bacterial pathogens to monitor the prevalence and any spatial-temporal patterns of AMR and to understand better how demographic, environmental and biological parameters may influence the emergence and spread of AMR in the community.     

See also:

https://www.researchgate.net/profile/Kazi_Md_Zillur_Rahman

https://scholar.google.com.au/citations?hl=en&user=Q-zCKmYAAAAJ

https://orcid.org/0000-0002-9857-6248

https://www.linkedin.com/in/kazi-md-zillur-rahman

Primary Supervisors: Professor Torsten Thomas, Professor Marylouise McLaws

Co-supervisor/s: Professor Stuart Khan, Dr Ori Gudes

 

PUBLICATIONS

Rahman Z, Rahman MA, Rashid MU, Monira S, Johura FT, Mustafiz M, Bhuyian SI, Zohura F, Parvin T, Hasan K, Saif-Ur-Rahman KM, Islam NN, Sack DA, George CM, Alam M., 2018. Vibrio cholerae Transmits Through Water Among the Household Contacts of Cholera Patients in Cholera Endemic Coastal Villages of Bangladesh, 2015-2016 (CHoBI7 Trial). Frontiers in Public Health, 6:238

George CM, Hasan K, Monira S, Rahman Z, Saif-Ur-Rahman KM, Rashid MU, Zohura F, Parvin T, Islam Bhuyian MS, Mahmud MT, Li S, Perin J, Morgan C, Mustafiz M, Sack RB, Sack DA, Stine OC, Alam M., 2018. A prospective cohort study comparing household contact and water Vibrio cholerae isolates in households of cholera patients in rural Bangladesh. PLoS neglected tropical diseases, 12(7), p.e0006641.

Islam, A., Rahman, Z., Monira, S., Rahman, M. A., Camilli, A., George, C. M., ... & Alam, M. (2017). Colistin resistant Escherichia coli carrying mcr-1 in urban sludge samples: Dhaka, Bangladesh. Gut pathogens, 9(1), 77.

Rahman Z, Islam A, Rashid MU, Johura FT, Monira S, Watanabe H, Ahmed N, Camilli A, Alam M., 2017. Existence of a novel qepA variant in quinolone resistant Escherichia coli from aquatic habitats of Bangladesh. Gut Pathogens, 9(1):58.

George, C.M., Rashid, M.U., Almeida, M., Saif-Ur-Rahman, K.M., Monira, S., Bhuyian, S.I., Hasan, K., Mahmud, M.T., Li, S., Jamie Perin, J.,Rahman, Z., Mustafiz, M., Sack, D., Sack, R.B, Munirul Alam, M., and Stine, OC., 2017. Genetic relatedness of Vibrio cholerae isolates within and between households during outbreaks in Dhaka, Bangladesh. BMC genomics,  18(1), p.903.

Monira, S., Shabnam, S.A., Ali, S.I., Sadique, A., Johura, F.T., Rahman, K.Z., Alam, N.H., Watanabe, H. and Alam, M., 2017. Multi-drug resistant pathogenic bacteria in the gut of young children in Bangladesh. Gut Pathogens9(1), p.19.

Burrowes, V., Perin, J., Monira, S., Sack, D.A., Rashid, M.U., Mahamud, T., Rahman, Z., Mustafiz, M., Bhuyian, S.I., Begum, F. and Zohura, F., 2017. Risk Factors for Household Transmission of Vibrio cholerae in Dhaka, Bangladesh (CHoBI7 Trial). The American Journal of Tropical Medicine and Hygiene, 96(6), pp.1382-1387.

Rafique, R., Rashid, M.U., Monira, S., Rahman, Z., Mahmud, M.T., Mustafiz, M., Saif-Ur-Rahman, K.M., Johura, F.T., Islam, S., Parvin, T. and Bhuyian, M.S.I., 2016. Transmission of Infectious Vibrio cholerae through Drinking Water among the Household Contacts of Cholera Patients (CHoBI7 Trial). Frontiers in Microbiology, 7.

Rashid, M.U., Rahman, Z., Burrowes, V., Perin, J., Mustafiz, M., Monira, S., Saif-Ur-Rahman, K.M., Bhuyian, S.I., Mahmud, M., Sack, R.B. and Sack, D., 2016. Rapid dipstick detection of Vibrio cholerae in household stored and municipal water in Dhaka, Bangladesh: CHoBI7 trial. Tropical Medicine & International Health.

Rashid, M.U., George, C.M., Monira, S., Mahmud, T., Rahman, Z., Mustafiz, M., Saif-Ur-Rahman, K.M., Parvin, T., Bhuyian, S.I., Zohura, F. and Begum, F., 2016. Chlorination of Household Drinking Water among Cholera Patients' Households to Prevent Transmission of Toxigenic Vibrio cholerae in Dhaka City: CHoBI7 Trial. The American Journal of Tropical Medicine and Hygiene, pp.16-0420.

George, C.M., Monira, S., Sack, D.A., Rashid, M.U., Saif-Ur-Rahman, K.M., Mahmud, T.,Rahman, Z., Mustafiz, M., Bhuyian, S.I., Winch, P.J. and Leontsini, E., 2016. Randomized controlled trial of hospital-based hygiene and water treatment intervention (CHoBI7) to reduce cholera. Emerging infectious diseases, 22(2), p.233.

George, C.M., Jung, D.S., Saif-Ur-Rahman, K.M., Monira, S., Sack, D.A., Rashid, M.U., Mahmud, T., Mustafiz, M., Rahman, Z., Bhuyian, S.I. and Winch, P.J., 2016. Sustained Uptake of a Hospital-Based Handwashing with Soap and Water Treatment Intervention (Cholera-Hospital-Based Intervention for 7 Days [CHoBI7]): A Randomized Controlled Trial. The American journal of tropical medicine and hygiene, 94(2), pp.428-436.

Mahmud AKMF, Rahman KMZ, Dey SK, Islam T, Talukder AA., 2014. Genome annotation and comparative genomics of Orf virus. Adv Microbiol, 4:1117–31.

George, C.M., Rashid, M.U., Sack, D.A., Bradley Sack, R., Saif-Ur-Rahman, K.M., Azman, A.S., Monira, S., Bhuyian, S.I., Rahman, K.M.Z., Toslim Mahmud, M. and Mustafiz, M., 2014. Evaluation of enrichment method for the detection of Vibrio cholerae O1 using a rapid dipstick test in Bangladesh. Tropical Medicine & International Health, 19 (3), pp.301-307.